{"id":37301,"date":"2025-05-20T12:25:20","date_gmt":"2025-05-20T05:25:20","guid":{"rendered":"https:\/\/1dddev.com\/physicssci\/?p=37301"},"modified":"2025-05-20T12:25:21","modified_gmt":"2025-05-20T05:25:21","slug":"dr-chalermpol-kanchanawarins-theoretical-and-computational-biophysics-group","status":"publish","type":"post","link":"https:\/\/1dddev.com\/physicssci\/dr-chalermpol-kanchanawarins-theoretical-and-computational-biophysics-group\/","title":{"rendered":"Dr. Chalermpol Kanchanawarin&#8217;s Theoretical and Computational Biophysics Group"},"content":{"rendered":"\n<p><strong>Lab Location<\/strong><\/p>\n\n\n\n<p>Laboratory of Theoretical and Computational Biophysics<\/p>\n\n\n\n<p>Room 451, 4th Floor, Physical Science (Sci 45 years) Building,<\/p>\n\n\n\n<p>Department of Physics, Faculty of Science.&nbsp;<\/p>\n\n\n\n<p><strong>Research Interests<\/strong><\/p>\n\n\n\n<p>My research group aims to understand how proteins work as nano-machines at atomic level. In particular, we use molecular dynamics simulations in combination with theoratical physics and data analysis from biochemical\/ biophysical experiments to investigate biomolecular motion and functions. &nbsp;Our current research topics are<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Ion conduction and\u00a0pore formation by\u00a0bacterial protein toxins<\/li>\n\n\n\n<li>Behaviours of water molecules around proteins and membranes<\/li>\n\n\n\n<li>Cytoskeletal polymerization of actin and actin like proteins<\/li>\n\n\n\n<li>Rotary mechanism and proton transport in biomolecular motors such as ATP synthase and\u00a0Flagellar motors<\/li>\n\n\n\n<li>Calcium-dependent membrane binding proteins (Annexin A5)<\/li>\n<\/ul>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"599\" height=\"265\" src=\"https:\/\/1dddev.com\/physicssci\/wp-content\/uploads\/2025\/05\/image-45.png\" alt=\"\" class=\"wp-image-37302\" srcset=\"https:\/\/1dddev.com\/physicssci\/wp-content\/uploads\/2025\/05\/image-45.png 599w, https:\/\/1dddev.com\/physicssci\/wp-content\/uploads\/2025\/05\/image-45-300x133.png 300w\" sizes=\"auto, (max-width: 599px) 100vw, 599px\" \/><\/figure>\n\n\n\n<p><strong>Figure 1<\/strong>&nbsp;shows 3D structure of a pore-forming protein (side and top view)<\/p>\n\n\n\n<p><strong>Group Members and Collaborations<\/strong><\/p>\n\n\n\n<p>Most of my research students whom I have been working with have personal interests in biology in some ways. They&nbsp;are not just physics students&nbsp;but also those from various other departments&nbsp;such as chemistry, biochemistry, medical technology, medicine, biology, and genetics etc. I am interested in taking some more research students. If you are interested in learning biophysics&nbsp;and are keen to learn how chemistry, physics, maths&nbsp;and computer&nbsp;are used to&nbsp;study biology then please come to talk to me.<\/p>\n\n\n\n<p>Principal Investigator<\/p>\n\n\n\n<p>Asst. Prof. Chalermpol Kanchanawarin (Ph.D. in physics, University of Illinois at Urbana-Champaign, USA; M.Phys. in physics, University of Oxford, UK)<\/p>\n\n\n\n<p>For more info about me please see\u00a0<a href=\"https:\/\/1dddev.com\/physicssci\/ku-personnel\/%e0%b8%9c%e0%b8%a8-%e0%b8%94%e0%b8%a3-%e0%b9%80%e0%b8%89%e0%b8%a5%e0%b8%b4%e0%b8%a1%e0%b8%9e%e0%b8%a5-%e0%b8%81%e0%b8%b2%e0%b8%8d%e0%b8%88%e0%b8%99%e0%b8%a7%e0%b8%a3%e0%b8%b4%e0%b8%99%e0%b8%97\/\" target=\"_blank\" rel=\"noreferrer noopener\">My home page<\/a>.<\/p>\n\n\n\n<p>Current students<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>2013-Present \u00a0 Ms. Chattip Kurehong (Ph.D. in\u00a0Molecular\u00a0Genetics and Genetics Engineering, Mahidol University)<\/li>\n\n\n\n<li>2014-Present \u00a0 Mr. Kanpong Boonthaworn (Ph.D. in Biology, Mahidol University)<\/li>\n\n\n\n<li>2014-Present \u00a0 Ms. Aunyamanee Preuksachonlatharn (B.S. in Physics, Kasetsart University)<\/li>\n\n\n\n<li>2014-Present \u00a0 Mr. Somsak Mongkon\u00a0(B.S. in Physics, Kasetsart University)<\/li>\n\n\n\n<li>2014-Present \u00a0 Ms. Intuon Chatratin\u00a0(B.S. in Physics, Kasetsart University)<\/li>\n\n\n\n<li>2015-Present \u00a0 Ms. Worachapar Bunyongkid\u00a0(B.S. in Physics, Kasetsart University)<\/li>\n<\/ul>\n\n\n\n<p>Previous students<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>2010-2014 \u00a0 \u00a0 \u00a0 Dr. Chompounoot Imtong (Ph.D. in Molecular\u00a0Genetics and Genetics Engineering, Mahidol University; Currently teaching in a university in Northern part of Thailand)<\/li>\n\n\n\n<li>2010-2013 \u00a0 \u00a0 \u00a0 Mr. Somyot Srikongrak (M.S. in Physics, Kasetsart University; Currently a lecturer at Rumpaipannee Rachapat University, Chantabury)<\/li>\n\n\n\n<li>2007-2010 \u00a0 \u00a0 \u00a0 Dr.\u00a0Taveechai Taveechareonkool\u00a0(M.D. Ph.D., Mahidol University and\u00a0\u00a0Siriraj Hospital; currently freelance medical doctor)\u00a0<\/li>\n\n\n\n<li>2007-2010\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Mr.\u00a0<a href=\"http:\/\/www.facebook.com\/witchukorn\" target=\"_blank\" rel=\"noreferrer noopener\">Witchukorn Phuthong\u00a0<\/a>(B.S. in Physics, Kasetsart University; currently a Ph.D. student doing Biophysics in Department of Materials at\u00a0Stanford university, US)<\/li>\n\n\n\n<li>2008-2010\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Ms.\u00a0<a href=\"http:\/\/www.facebook.com\/people\/Pattama-Wapeesittipan\/100000903337851\" target=\"_blank\" rel=\"noreferrer noopener\">Pattama Wapeesittipan\u00a0<\/a>(M.S. in Chemistry, Chulalongkorn University; B.S. in Chemistry, Mahidol University; currently doing D.Phil. in chemistry at Edinburgh University, UK)<\/li>\n<\/ul>\n\n\n\n<p>Collaborations<\/p>\n\n\n\n<p>I&nbsp;belief that one of the best ways to solve a biophysics problem is to work closely with experimentalists who work on that problem. Over the past&nbsp;several years, I have had a great pleasure working with&nbsp;the following people.&nbsp;We have learned a lot from each other.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"http:\/\/www.mb.mahidol.ac.th\/mben\/index.php\/addressbook\/c\/chanan-angsuthanasombatassoc-prof\">Prof. Chanan Angsuthanasombat\u00a0<\/a>(experimental biochemist and biophysicist), Institute of Molecular Biosciences, Mahidol university (Salaya campus), Nakorn Pratom, Thailand.<\/li>\n\n\n\n<li>Dr. Puey Ounjai (Experimental Biophysicist), Department of Biology, Mahidol university, Bangkok, Thailand.<\/li>\n<\/ul>\n\n\n\n<p><strong>Publications<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"http:\/\/www.mdpi.com\/2072-6651\/7\/5\/1486\/htm\">Kurehong, C., Kanchanawarin, C., Powthongchin, B., Katzenmeier, G., and Angsuthanasombat, C. (2015) Membrane-pore formation characteristics of the Bordetella pertussis CyaA-Hymolysin Domain, Toxins, 7(5) p1486-96.<\/a>\u00a0[IF=2.48]<\/li>\n\n\n\n<li><a href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S1570963914000533\">Imtong, C., Kanchanawarin, C., Katzenmeier, G., and Angsuthanasombat, C. (2014) Bacillusthuringiensis Cry4Aa insecticidal protein: functional importance of intrinsic stability of the unqique\u00a0<\/a><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24120447\">\u03b14\u2013\u03b15<\/a><a href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S1570963914000533\">\u00a0loop comprising the Pro-rich sequence. BBA Proteins and Proteomics, 1844(6) p.1111-8.<\/a>\u00a0[IF=3.19]<\/li>\n\n\n\n<li><a href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0005273613003556\">Juntadech, T., Kanintronkul, C., Kanchanawarin, C., Katzenmeier, G., \u00a0and Angsuthanasombat, C. (2014). Importance of polarity of the\u00a0<\/a><strong><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24120447\">\u03b14\u2013\u03b15<\/a>\u00a0<\/strong><a href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0005273613003556\">loop residue &#8211; Asn166 in the pore-forming domain of the Bacillus thuringiensis Cry4Ba toxin: Implication for ion premeation and pore opening.<\/a><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24120447\">\u00a0BBA Biomembranes, 1838(1), p.319-327.<\/a>\u00a0[IF=3.43]<\/li>\n\n\n\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3239330\/\">Taveecharoenkool, T,\u00a0Angsuthanasombat C,\u00a0Kanchanawarin C. \u00a0(2010) \u00a0Combined molecular dynamics and continuum solvent studies of the pre-pore Cry4Aa trimer suggest its stability in solution and how it may form pore. PMC Biophysics. 3(10)<\/a><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3239330\/\">.<\/a>\u00a0[IF=2.18]<\/li>\n<\/ul>\n\n\n\n<p><strong>Research Facilities<\/strong><\/p>\n\n\n\n<p>We have a high performance computing facility. Together with Asst. Prof. Jiraroj T-Tienprasert,&nbsp;we have designed, built, managed the following computer systems<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>a\u00a0<a href=\"http:\/\/www.rocksclusters.org\/\">Rocks computer cluster\u00a0<\/a>consisting of 16 blade servers each with dual quad-core\u00a0Opteron CPUs running\u00a0<a href=\"http:\/\/www.ks.uiuc.edu\/Research\/namd\">NAMD<\/a>\u00a0programs for doing large scale\u00a0molecular dynamics simulations (upto about one million atoms).<\/li>\n\n\n\n<li>two visualization\u00a0Linux workstations consisting of dual quad-core Xeon CPUs with high-end graphics, stereographics glasses and large memory for analysis of large\u00a0trajectories of\u00a0MD data using\u00a0<a href=\"http:\/\/www.ks.uiuc.edu\/Research\/vmd\">VMD<\/a>\u00a0program.<\/li>\n<\/ul>\n\n\n\n<p>Note: These&nbsp;machines will not be possible without the support&nbsp;from the following research grants and agencies; 1)&nbsp;Kasetsart University Research and Development Institute (KURDI) Grants for Dr. Chalermpol (# Wor-Tor(Dor)27.51) and&nbsp; KURDI Grant for Dr. Wiwat, 2) Thailand Research Fund (TRF) Grant No. MRG5180355 for Dr. Chalermpol and TRF Grant for Dr. Palawan, 3)&nbsp;Science Research Fund (ScRF) Grant No. SCRF-E10\/2551 from the faculty of science at Kasetsart University, 4) Some funding from a research grant of Dr. Chanan at Mahidol University, 5) Funding from Physics Department, Kasetsart University, 6) Help from technicians&nbsp;from the faculty of science, Kasetsart university.<\/p>\n\n\n\n<p><strong>Funding Resources<\/strong><\/p>\n\n\n\n<p>Previously, our research group was funded by the following funding agencies.<\/p>\n\n\n\n<p>1. KURDI (Kasetsart University Research and Development Institute<\/p>\n\n\n\n<p>2. TRF (Thailand Research Fund)<\/p>\n\n\n\n<p>3. Faculty of Science, Kasetsart University<\/p>\n\n\n\n<p>4. ThEP Center (Thailand Center of Excellence in Physics)<\/p>\n\n\n\n<p>5. Department of Physics, Kasetsart University<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Lab Location Laboratory of Theoretical and Computational Biophysics Room 451, 4th Floor, Physical Science (Sci 45 years) Building, Department of Physics, Faculty of Science.&nbsp; Research Interests My research group aims to understand how proteins work as nano-machines at atomic level. In particular, we use molecular dynamics simulations in combination with theoratical physics and data analysis [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"tags":[],"news_cate":[174],"class_list":["post-37301","post","type-post","status-publish","format-standard","hentry","news_cate-174"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.3 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Dr. Chalermpol Kanchanawarin&#039;s Theoretical and Computational Biophysics Group - \u0e20\u0e32\u0e04\u0e27\u0e34\u0e0a\u0e32\u0e1f\u0e34\u0e2a\u0e34\u0e01\u0e2a\u0e4c \u0e04\u0e13\u0e30\u0e27\u0e34\u0e17\u0e22\u0e32\u0e28\u0e32\u0e2a\u0e15\u0e23\u0e4c \u0e21\u0e2b\u0e32\u0e27\u0e34\u0e17\u0e22\u0e32\u0e25\u0e31\u0e22\u0e40\u0e01\u0e29\u0e15\u0e23\u0e28\u0e32\u0e2a\u0e15\u0e23\u0e4c<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/1dddev.com\/physicssci\/dr-chalermpol-kanchanawarins-theoretical-and-computational-biophysics-group\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Dr. Chalermpol Kanchanawarin&#039;s Theoretical and Computational Biophysics Group - \u0e20\u0e32\u0e04\u0e27\u0e34\u0e0a\u0e32\u0e1f\u0e34\u0e2a\u0e34\u0e01\u0e2a\u0e4c \u0e04\u0e13\u0e30\u0e27\u0e34\u0e17\u0e22\u0e32\u0e28\u0e32\u0e2a\u0e15\u0e23\u0e4c \u0e21\u0e2b\u0e32\u0e27\u0e34\u0e17\u0e22\u0e32\u0e25\u0e31\u0e22\u0e40\u0e01\u0e29\u0e15\u0e23\u0e28\u0e32\u0e2a\u0e15\u0e23\u0e4c\" \/>\n<meta property=\"og:description\" content=\"Lab Location Laboratory of Theoretical and Computational Biophysics Room 451, 4th Floor, Physical Science (Sci 45 years) Building, Department of Physics, Faculty of Science.&nbsp; Research Interests My research group aims to understand how proteins work as nano-machines at atomic level. 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