ผศ. ดร. สุนิสา อัคคะรัสมิโย

วุฒิการศึกษา

• Postdoc (Organic chemistry) Stockholm University, Sweden
• Postdoc (Organic chemistry) Uppsala University, Sweden
• Ph.D. (Chemistry), Kasetsart University, Bangkok, Thailand
• M.Sc. (Organic Chemistry), Silpakorrn University, Nakhon Pathom, Thailand
• B.Sc. (Chemistry) Silpakorrn University, Nakhon Pathom, Thailand

งานวิจัย

Our research works focus on development of synthetic methodology and synthesis of biologically active compounds based on green chemistry concept.

1. C-O bond cleavage of alcohols and ethers
   • Deoxygenation of epoxides to alkenes
     This methodology could be an alternative approach for alkene isomerization and also one of the method for utilization of biomass as renewable chemicals.
   • Suzuki-Miyaura cross-coupling of benzylic alcohols
     C(sp³)-C(sp²) bond formation via Suzuki-Miyaura cross-coupling of non-derivatized benzylic alcohols is a greener alternative method to use benzylic halides is ongoing to develop.
2. 2. Asymmetric synthesis of biologically active molecules
   • 2.1 Synthesis of Chrysosporazine A-C

References : Org. Lett. 2019, 21, 4782-4787, Synthesis 2020, 52, 645-659.

ผลงานวิจัย

• Akkarasamiyo, S.; Rujirawat, S.; Ploypradith, P.; Samec, J.S.M. Transition-Metals Catalyzed Suzuki-Miyaura Type Cross Coupling Reaction of p-Activated Alcohols Synthesis 2020, 52(5), 645-659
• Akkarasamiyo, S.; Samec, J.S.M. Intermolecular Stereospecific Substitution of Underivatized Enantioenriched Secondary Alcohols by Organocatalysis (Highlight) Angew. Chem. Int. Ed. 2019, 58(50), 17908-17910.
• Watile, R. A.; Bunrit, A.; Margalef, J.; Akkarasamiyo, S.; Ayub, R.; Lagerspets, E.; Biswas, S.; Repo, T.; Samec, J.S.M. Intramolecular substitutions of secondary and tertiary alcohols with chirality transfer by an iron (III) catalyst Nature Comm. 2019, 10:3826.
• Akkarasamiyo, S.; Margalef, J.; Samec, J. S. M. Nickel-Catalyzed Suzuki-Miyaura Cross-Coupling Reaction of Naphthyl and Quinolyl Alcohols with Boronic Acids Org. Lett. 2019, 21, 4782-4787.
• Rukkijakan, T.; Akkarasamiyo, S.; Sawadjoon, S.; Samec, J. S. M. Pd-catalyzed substitution of the OH group of non-derivatized allylic alcohols by phenols J. Org. Chem. 2018, 83(7), 4099-4104.
• Akkarasamiyo, S.; Sawadjoon, S.; Orthaber, A.; Samec, J. S. M. Tsuji-Trost Reaction of Non-Derivatized Allylic Alcohols. Chem. Eur. J.  2018, 24(14), 3488–3498.
• Gupta, A. K.; Akkarasamiyo, S.; Orthaber, A. Rich Coordination Chemistry of π‑Acceptor Dibenzoarsole Ligands. Inorg. Chem. 2017, 56, 4504−4511.