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หน้าหลัก >  บุคลากร > รศ.ดร. พิทักษ์ เชื้อวงศ์

รศ.ดร. พิทักษ์ เชื้อวงศ์

fsciptcw@ku.ac.th

วุฒิการศึกษา

  • Ph.D. (Organic and Bio-Organic Chemistry), The Johns Hopkins University, USA
  • M.A (Organic and Bio-Organic Chemistry), The Johns Hopkins University, USA
  • M.S. (Organometallic Chemistry), Oregon State University, USA
  • B.Sc. (Chemistry) (1st class honors), Kasetsart University

งานวิจัย

The PC research group utilizes chemistry as a tool for solving biological problems. The multidisciplinary approach currently used in our lab is the key to answer several intricate and challenging biological questions in the area of molecular evolution, protein biosynthesis, and molecular biology. The major research project in PC lab concerns a group of enzymes called aminoacyl-tRNA synthetases (AARSs).

Our research interests also extend toward the field of bioconjugate chemistry. Using the new chemical approach, new bioconjugate molecules with different chemical properties are designed and synthesized. These molecules can be used as new chemical linkers for different types of biomolecules including proteins, carbohydrates, DNA, and RNA.

Bioorganic Chemistry
Indirect tRNA Aminoacylation in the Human Pathogen Helicobacter Pylori

The ultimate goal of this project is to better understand the indirect aminoacylation pathway used by Helicobacter pylori. The information obtained from our study will pave the new road for the discovery of a new antibiotic drug with novel mechanism of action.

  • Fuengfuloy, P., Chuawong, P., Suebka, S., Wattana-amorn, P., Williams, C., Crump, M., Songsiriritthigul, C., Protein Expr Purif., 2013, 89, 25-32.
  • Silva, G. N., Fatma, S., Floyd, A. M., Fischer, F., Chuawong, P., Cruz, A. N., Simari, R. M., Joshi, N., Kern, D., Hendrickson, T. L., J. Biol. Chem., 2013, 288, 3816-3822.

Physical Organic Chemistry

Regioselectivity of the Larock Heteroannulation Reaction

Our lab is particularly interested in the electronic effect on the regioselectivity of the Larock Heteroannulation. We have demonstrated, experimentally and computationally, that the resulting indole product is formed with greater electron density carbon at the 2-position.

  • Phetrak, N., Rukkijakan, T., Sirijaraensre, J., Prabpai, S., Kongsaeree, P., Klinchan, C., Chuawong, P., J. Org. Chem., 2013, Article ASAP, DOI: 10.1021/jo402304s

Research Focus [R4:Human and Animal Health]

ผลงานวิจัย

  1. Rukkijakan, T., Ngiwsara, L., Lirdprapamongkol, K., Svasti, J., Phetrak, N., Chuawong, P.. 2018. “A SYNTHETIC 2,3-DIARYLINDOLE INDUCES CELL DEATH VIA APOPTOSIS AND AUTOPHAGY IN A549 LUNG CANCER CELLS”. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 26(9): 2119-2123 DOI: 10.1016/j.bmcl.2016.03.079
  2. Songsiriritthigul, C., Suebka, S., Chen, C., Fuengfuloy, P., Chuawong, P. . 2017. “CRYSTAL STRUCTURE OF THE N-TERMINAL ANTICODONBINDING DOMAIN OF THE NONDISCRIMINATING A SPARTYL-TRNA SYNTHETASE FROM HELICOBACTER PYLORI”.  ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS. 73: 62-69 .DOI: 10.1107/S2053230X16020586
  3. Rukkijakan, T., Ngiwsara, L., Lirdprapamongkol, K., Svasti, J., Phetrak, N., Chuawong, P.. 2016. “A SYNTHETIC 2,3-DIARYLINDOLE INDUCES CELL DEATH VIA APOPTOSIS AND AUTOPHAGY IN A549 LUNG CANCER CELLS”. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 26(9): 2119-2123 . DOI: 10.1016/j.bmcl.2016.03.079
  4. Theppawong, A., P. Ploypradith, P. Chuawong, S. Ruchirawat, M. Chittchang. 2015. “Facile and Divergent Synthesis of Lamellarins and Lactam-Containing Derivatives with Improved Drug Likeness and Biological Activities” Chem. Asian J.10(12):2631-2650.
  5. Klinchan, C., Y. Hsu, L. Lo, W. Pluempanupat, P. Chuawong. 2014. “Synthesis of Non-Hydrolyzable Substrate Analogs for Asp-tRNAAsn/Glu-tRNAGln Amidotransferase” Tetrahedron Lett. 55(45): 6204-6207. DOI: 10.1016/j.tetlet.2014.09.060
  6. Phetrak, N., T. Rukkijakan, J. Sirijaraensre, S. Prabpai, P. Kongsaeree, C. Klinchan, P. Chuawong. 2013. “Regioselectivity of Larock Heteroannulation: A Contribution from Electronic Properties of Diarylacetylenes” J. Org. Chem. 78(24): 12703-12709.
  7. Fuengfuloy, P., P. Chuawong, S. Suebka, P. Wattana-amorn, C. Williams, M. Crump, C. Songsiriritthigul. 2013. “Overproduction of the N-terminal Anticodon-binding Domain of the Non-discriminating Aspartyl-tRNA Synthetase from Helicobacter pylori for Crystallization and NMR Measurements” Protein Expr. Purif. 89: 25-32.
  8. Silva, G. N., S. Fatma, A. M. Floyd, F. Fischer, P. Chuawong, A. N. Cruz, R. M. Simari, N. Joshi, D. Kern, T. L. Hendrickson. 2013. “A tRNA-independent Mechanism for Transamidosome Assembly Promotes Aminoacyl-tRNA Transamidation” J. Biol. Chem. 288: 3816-3822.
  9. Cathopoulis, T., Chuawong, P., and Hendrickson, T. L., “Novel tRNA Aminoacylation Mechanisms”, Molecular Biosystems, Biochemistry, 2008, 47(29), 7610-6
  10. Cathopoulis, T., Chuawong, P., and Hendrickson, T. L., “Novel tRNA Aminoacylation Mechanisms”, Molecular Biosystems, 2007, 3, 408-418
  11. Cathopoulis, T. , Chuawong, P. , and Hendrickson, T. L., “A Thin-Layer Electrophoretic Assay for Asp-tRNAAsn/Glu-tRNAGln Amidotransferase”, Anal. Biochem., 2007, 360, 151-153.
  12. Stanley, A. M. , Chuawong, P. , Hendrickson, T. L. , and Fleming, K. G., “Lipid Chain Selectivity by Outer Membrane Phospholipase A” , J. Mol. Biol., 2006, 366(2), 461-8.
  13. Chuawong, P., Hendrickson, T. L., “The Nondiscriminating Aspartyl-tRNA Synthetase from Helicobacter pylori: Anticodon-Binding Domain Mutations That Impact tRNA Specificity and Heterologous Toxicity”, Biochemistry, 2006, 45(26), 8079-8087
  14. Stanley, A. M., Chuawong, P. , Hendrickson, T. L., Fleming, K.G., “Energetics of outer membrane phospholipase A (OMPLA) dimerization.”, J. Mol. Biol., 2006 , 358(1), 120-31
  15. Gable, K. P., Khownium, K., Chuawong, P. , “Reaction of Strained-Ring Heterocycles with a Rhenium(V) Dioxo Complex”, Organometallics, 2004, 23(22), 5268-5274
  16. Gable, K. P., Chuawong, P., Yokochi, A. F. T., “Thermal Stability of Tris(3,5-dimethylpyrazolyl)hydridoboratorhenium(V)(oxo)- (1,2-dithiolate) and -(1,2-monothiodiolate) Complexes and DFT Studies of C-S Bond Cleavage”, Organometallics, 2002, 21(5), 929-933