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หน้าหลัก >  บุคลากร > รศ.ดร. พัชรีนารถ ทรัพย์อาภากร

รศ.ดร. พัชรีนารถ ทรัพย์อาภากร

fscipnsk@ku.ac.th

วุฒิการศึกษา

  • Ph.D. (Chemistry), Kasetsart University
  • B.Sc. (Chemistry, 2nd Class Honours), Kasetsart University

งานวิจัย

  • Computer-aided drug design (ex. Virtual Screening, Molecular Docking, Quantitative Structure Activity Relationship (QSAR)), HIV-1 RT 
  • To better understand the key interaction of drugs or molecules in the biological targets and predict the photophysical properties which will be helpful for designing the new potent compounds
  • Using Molecular docking and quantum chemical calculations
    1. Divide-and-conquer based quantum chemical study
      • Interaction between HIV-1 RT and NNRTIs
      • Mechanism of the West Nile Virus NS3 Protease Inhibitor
      • Other targets; ex. Dengue virus, Alzheimer disease etc.
    2. Binding and photophysical investigation of DNA intercalating dye
      • Adsorption and emission properties of fluorescence dyes; ex. picogreen, used in the biological assay
    3. Determination of the absolute configuration using electronic circular dichroism spectra
      • Assign the absolute configuration of the natural compounds

ผลงานวิจัย

  1. Saparpakorn P, Hannongbua S, Rognan D. Design of nevirapine derivatives insensitive to the K103N and Y181C HIV-1) reverse transcriptase mutants. SAR QSAR Environ Res., 2006, 17, 183-94.
  2. Pungpo P, Saparpakorn P, Wolschann P, Hannongbua S. Computer-aided molecular design of highly potent HIV-1 RT inhibitors: 3D QSAR and molecular docking studies of efavirenz derivatives. SAR QSAR Environ Res. 2006, 17, 353-70.
  3. Khunnawutmanotham N, Chimnoi N, Saparpakorn P, Pungpo P, Louisirirotchanakul S, Hannongbua S, Techasakul S. Novel 2-chloro-8-arylthiomethyldipyridodiazepi-none derivatives with activity against HIV-1 reverse transcriptase. Molecules 2007, 12, 218-230.
  4. Saparpakorn P, Kim J, Hannongbua S. Investigation on the binding of polycyclic aromatic hydrocarbons with soil organic matter; A theoretical approach., Molecules 2007, 12, 703-715.
  5. Pungpo P, Punkvang A, Saparpakorn P, Hannongbua S. Chapter VIII – Understanding the Interaction and the Structure-Activity Correlation of HIV-1 RT Inhibitors of Efavirenz Derivatives and WT and K103N HIV-1 RT using Molecular Docking, 3D-QSAR Approaches and Quantum Chemical Calculations, Drug Design Research Perspectives , 2007, 213-249.
  6. Pungpo P, Punkvang A, Saparpakorn P, Hannongbua S. Understanding the interaction and the structure-activity correlation of efavirenz derivatives and WT and K103N HIV-1 RT by molecular docking and 3D-QSAR approaches, Infect. Gen. Evol., 2008, 8, S43.
  7. Ming Ge H., Yun Zhang W., Ding G., Saparpakorn P., Chun Song Y., Hannongbua S., Xiang Tan R. Chaetoglobins A and B, two unusual alkaloids from endophytic Chaetomium globosum culture, Chem. Comm. 2008, 45, 5978-5980
  8. Saparpakorn, P., M. Kobayashi, H. Nakai. 2013. “Divide-and-Conquer Electronic-Structure Study on the Mechanism of the West Nile Virus NS3 Protease Inhibitor” Bull. Chem. Soc. Jpn.86: 67-74.
  9. Saparpakorn, P., M. Kobayashi, S. Hannongbua, H. Nakai. 2013. “Divide-and-Conquer Based Quantum Chemical Study for Interaction between HIV-1 Reverse Transcriptase and MK-4965 Inhibitor” Int. J. Quant. Chem. 113: 510-517.
  10. Okoshi M., P. Saparpakorn, Y. Takada, S. Hannongbua, H. Nakai. 2014. “Theoretical Study on the Selective Fluorescence of PicoGreen: Binding Models and Photophysical Properties” Bull. Chem. Soc. Jpn. 87: 267-273.
  11. Kamsri, P., A. Punkvang, S. Hannongbua, P. Saparpakorn, P. Pungpo. 2015. “Elucidating Structural Basis of Benzofuranpyrrolidinepyrazole Derivatives for Enhancing Potency against Both the InhA Enzyme and Intact M. Tuberculosis Cells: ACombined MD Simulations and 3D-QSAR Study” RSC Adv. 5: 52926-52937.