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หน้าหลัก >  บุคลากร > รศ.ดร. ปกรณ์ วรรธนะอมร

รศ.ดร. ปกรณ์ วรรธนะอมร

fscipwa@ku.ac.th

วุฒิศึกษา

  • Ph.D. (Chemistry), University of Bristol, UK (2003-2007)
  • B.Sc. (Chemistry)(1st Class Honours), Kasetsart University (1999-2003)

Work experience

  • BBSRC postdoctoral fellowship, University of Bristol, UK (2007-2009)

งานวิจัย

  • Enzymology in the Biosynthesis of Polyketides
  • Natural Product Chemistry
  • Protein Chemistry
  • Biological NMR

ผลงานวิจัย

Publications

2022

  1. Promsuk G, Vuttipongchaikij S, Prommarit K, Suttangkakul A, Lazarus CM, Wonnapinij P, Wattana-Amorn P. (2022) Anthranilic acid accumulation in Saccharomyces cerevisiae induced by expression of a nonribosomal peptide synthetase gene from Paecilomyces cinnamomeus BCC 9616. Chembiochem. 23(24), e202200573.
  2. Phakeovilay, J., Imaram, W., Vuttipongchaikij, S., Bunnak, W., Lazarus, C.M., Wattana-Amorn, P. (2022) C-methylation controls the biosynthetic programming of alternapyrone. Org. Biomol. Chem. 20, 5050-4.
  3. Kaewtathip, T., Wattana-Amorn, P., Boonsupthip, W., Lorjaroenphon, Y., Klinkesorn, U. (2022) Maillard reaction products-based encapsulant system formed between chitosan and corn syrup solids: Influence of solution pH on formation kinetic and antioxidant activity. Food Chem. 393,133329.
  4. Leetanasaksakul, K., Koomsiri, W., Suga, T., Matsuo, H., Hokari, R., Wattana-Amorn, P., Takahashi, Y.K., Shiomi, K., Nakashima, T., Inahashi, Y., Thamchaipenet, A. (2022) Sattahipmycin, a hexacyclic xanthone produced by a marine-derived Streptomyces. J. Nat. Prod. 85(5), 1211-1217.
  5. Promsuk, G., Chuawong, P., Songjanthuek, P., Thaisri, S., Yongsmith, B., Wattana-Amorn, P. (2022) Absolute configuration of azaphilones from Monascus kaoliang KB9 and solvent effects on their keto and enol forms. Nat. Prod. Res. doi: 10.1080/14786419.2022.2034812.

2021

  1. Thongkawphueak, T., Winter, A.J., Williams, C., Maple, H.J., Soontaranon, S., Kaewhan, C., Campopiano, D.J., Crump, M.P., Wattana-Amorn, P. (2021) Solution structure and conformational dynamics of a doublet acyl carrier protein from prodigiosin biosynthesis. Biochemistry. 60, 219-230.
  2. Bunnak, W., Winter, A.J., Lazarus, C.M., Crump, M.P., Race, P.R., Wattana-Amorn, P. (2021) SAXS reveals highly flexible interdomain linkers of tandem acyl carrier protein-thioesterase domains from a fungal nonreducing polyketide synthase. FEBS lett. 595, 133-144.
  3. Songjanthuek, P., Saleepochn, T., Pluempanupat, W., Yongsmith, B., Kongkathip, B., Wattana-Amorn, P. (2021) Combination of 1H and 13C NMR for quantitative analysis of the orange pigments produced by Monascus kaoliang KB9 . Nat. Prod. Res. doi: 10.1080/14786419.2021.2010197.

2020

  1. Thenchartanan, P., Wattana-Amorn, P. , Svasti, J. , Kongsaeree, P.T. (2020) Improved synthesis of long-chain alkyl glucosides catalyzed by an engineered β-glucosidase in organic solvents and ionic liquids. Biotechnol Lett. 42, 2379-2387.
  2. Thenchartanana,P., Pitchayatanakorna,P., Wattana-Amorn, P., Ardac,A., Svasti,J., Jimenez-Barberoc,J.,Kongsaereea,P.T. (2020) Synthesis of long-chain alkyl glucosides via reverse hydrolysis reactions catalyzed by an engineered β-glucosidase. Enzyme Microbial Tech. 140, 109591.

2019

  1. Koomsiri, W., Inahashi, Y., Leetanasaksakul, K., Shiomi, K., Takahashi, Y.K., OMura, S., Samborskyy, M., Leadlay, P.F., Wattana-Amorn, P., Thamchaipenet, A., Nakashima, T. (2019) Sarpeptins A and B, Lipopeptides Produced by Streptomyces sp. KO-7888 Overexpressing a Specific SARP Regulator. J. Nat. Prod. 82(8), 2144-2151.
  2. Bunnak, W., Wonnapinij, P., Sriboonlert, A., Lazarus, C.M., Wattana-Amorn, P. (2019) Heterologous biosynthesis of a fungal macrocyclic polylactone requires only two iterative polyketide synthases. Org. Biomol. Chem. 17, 374-379.

2018

  1. Arthornthurasuk, S., Jenkhetkan, W., Suwan, E., Chokchaichamnankit, D., Srisomsap, C., Wattana-Amorn, P., Svasti, J., Kongsaeree, P.T. (2018) Molecular Characterization and Potential Synthetic Applications of GH1 β-Glucosidase from Higher Termite Microcerotermes annandalei. Appl. Biochem. Biotechnol. 186, 877-894.
  2. Jackson, D.R., Shakya, G., Patel, A.B., Mohammed, L.Y., Vasilakis, K., Wattana-Amorn, P., Valentic, T.R., Milligan, J.C., Crump, M.P., Crosby, J., Tsai, S.C. (2018) Structural and Functional Studies of the Daunorubicin Priming Ketosynthase DpsC. ACS Chem. Biol. 13(1), 141-151.

2016

  1. Wattana-Amorn, P., Charoenwongsa, W., Williams, C., Crump, M.P., Apichaisataienchote, B. (2016) Antibacterial activity of cyclo(L-Pro-L-Tyr) and cyclo(D-Pro-L-Tyr) from Streptomyces sp. strain 22-4 against phytopathogenic bacteria. Nat. Prod. Res. 30(17), 1980-3.

2015

  1. Sappakhaw, K., Takasila, R., Sittikul, P., Wattana-Amorn, P., Assavalapsakul, W., Boonyalai, N. (2015) Biochemical characterization of plasmepsin V from Plasmodium vivax Thailand isolates: Substrate specificity and enzyme inhibition. Mol. Biochem. Parasitol. 204(2), 51-63.
  2. Choengpanya, K., Arthornthurasak, S., Wattana-Amorn, P., Huang, W.T., Plengmuankhae, W., Li, Y.K, Kongsaeree, P.T. (2015) Cloning, expression and characterization of β-xylosidase from Aspergillus niger ASKU28. Protein. Expr. Purif. 115, 132-140

2013

  1. Haines, A.S., Dong, X., Song, Z., Farmer, R., Williams, C., Hothersall, J., Płoskoń, E., Wattana-Amorn, P., Stephens, E.R., Yamada, E., Gurney, R., Takebayashi, Y., Masschelein, J., Cox, R.J., Lavigne, R., Willis, C.L., Simpson, T.J., Crosby, J., Winn, P.J., Thomas, C.M., Crump, M.P. (2013) A conserved motif flags acyl carrier proteins for β-branching in polyketide synthesis. Nat. Chem. Biol. 9, 685-92.
  2. Wattana-Amorn, P., Juthaphan, P., Sirikamonsil, M., Sriboonlert, A., Simpson, T.J., Kongkathip, N. (2013) Biosynthetic Origins of Menisporopsin A. J. Nat. Prod. 76, 1235-1237.
  3. Fuengfuloy, P., Chuawong, P., Suebka, S., Wattana-Amorn, P., Williams, C., Crump, M.P., Songsiriritthigul, C. (2013) Overproduction of the N-terminal anticodon-binding domain of the non-discriminating aspartyl-tRNA synthetase from Helicobacter pylori for crystallization and NMR measurements. Protein. Expr. Purif. 89, 25-32.

2012

  1. Williams, C., Hoppe, H.J., Rezgui, D., Strickland, M., Forbes, B.E., Grutzner, F., Frago, S., Ellis, R.Z., Wattana-Amorn, P., Prince, S.N., Zaccheo, O.J., Nolan, C.M., Mungall, A.J., Jones, E.Y., Crump, M.P., Hassan, A.B. (2012) An exon splice enhancer primes IGF2:IGF2R binding site structure and function evolution. Science 338, 1209-13.

2010

  1. Ploskon, E., Arthur, C., Kanari, A.L., Williams, C., Wattana-amorn, P., Willis, C.L., Simpson, T. J., Crosby, J., Crump, M.P. (2010) Recognition of intermediate functionality by acyl carrier protein over a complete cycle of fatty acid biosynthesis. Chem Biol. 17, 776-85.
  2. Wattana-amorn, P., Williams, C., Ploskon, E., Cox, R. J., Simpson, T. J., Crosby, J., Crump, M.P. (2010) Solution Structure of an acyl carrier protein domain from a fungal type I polyketide synthase. Biochemistry 49, 2186-93.

2009

  1. Evans, S. E., Williams, C., Arthur, C. J., Ploskon, E., Wattana-amorn, P., Cox, R. J., Crosby, J., Willis, C. L., Simpson, T. J., and Crump, M. P. (2009) Probing the Interactions of early polyketide intermediates with the Actinorhodin ACP from S. coelicolor A3(2). J Mol Biol 389, 511-28.

2008

  1. Castaldo, G., Zucko, J., Heidelberger, S., Vujaklija, D., Hranueli, D., Cullum, J., Wattana-amorn, P., Crump, M.P., Crosby, J., Long, P.F. (2008) Proposed arrangement of proteins forming a bacterial type II polyketide synthase. Chem Biol 15, 1156-65.