{"id":35005,"date":"2025-06-12T14:35:56","date_gmt":"2025-06-12T07:35:56","guid":{"rendered":"https:\/\/1dddev.com\/biochemistrysci\/?post_type=ku-personnel&#038;p=35005"},"modified":"2025-06-12T15:06:12","modified_gmt":"2025-06-12T08:06:12","slug":"%e0%b8%a3%e0%b8%ad%e0%b8%87%e0%b8%a8%e0%b8%b2%e0%b8%aa%e0%b8%95%e0%b8%a3%e0%b8%b2%e0%b8%88%e0%b8%b2%e0%b8%a3%e0%b8%a2%e0%b9%8c-%e0%b8%94%e0%b8%a3-%e0%b8%93%e0%b8%b1%e0%b8%90%e0%b8%99%e0%b8%b1%e0%b8%99","status":"publish","type":"ku-personnel","link":"https:\/\/1dddev.com\/biochemistrysci\/ku-personnel\/%e0%b8%a3%e0%b8%ad%e0%b8%87%e0%b8%a8%e0%b8%b2%e0%b8%aa%e0%b8%95%e0%b8%a3%e0%b8%b2%e0%b8%88%e0%b8%b2%e0%b8%a3%e0%b8%a2%e0%b9%8c-%e0%b8%94%e0%b8%a3-%e0%b8%93%e0%b8%b1%e0%b8%90%e0%b8%99%e0%b8%b1%e0%b8%99\/","title":{"rendered":"\u0e23\u0e2d\u0e07\u0e28\u0e32\u0e2a\u0e15\u0e23\u0e32\u0e08\u0e32\u0e23\u0e22\u0e4c \u0e14\u0e23.\u0e13\u0e31\u0e10\u0e19\u0e31\u0e19\u0e17\u0e4c \u0e15.\u0e40\u0e17\u0e35\u0e22\u0e19\u0e1b\u0e23\u0e30\u0e40\u0e2a\u0e23\u0e34\u0e10"},"content":{"rendered":"\n<p><strong>Fax : <\/strong>+662-561-4627<\/p>\n\n\n\n<p><strong>Education Background<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>2007 Ph.D (Biochemistry) Univesity of Otago, New Zealand<\/li>\n\n\n\n<li>2003 B.Sc (Hons) (Biochemistry) University of Otago, New Zealand<\/li>\n<\/ul>\n\n\n\n<p><strong>Area of Expertise<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Molecular Virology<\/li>\n\n\n\n<li>Molecular Biology<\/li>\n\n\n\n<li>Bioinformatic analysis on nucleotides<\/li>\n<\/ul>\n\n\n\n<p><strong>Research Interests<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Functional regulatory elements within hepatitis B virus (HBV)<\/li>\n\n\n\n<li>RNA-protein interaction between HBV RNA and cellular proteins<\/li>\n\n\n\n<li>Inhibition of HBV gene expression by RNA interference technique<\/li>\n\n\n\n<li>Anti-cancer activities from natural products<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Research focus<\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"723\" height=\"1024\" src=\"https:\/\/1dddev.com\/biochemistrysci\/wp-content\/uploads\/2025\/06\/image-8-723x1024.png\" alt=\"\" class=\"wp-image-35029\" srcset=\"https:\/\/1dddev.com\/biochemistrysci\/wp-content\/uploads\/2025\/06\/image-8-723x1024.png 723w, https:\/\/1dddev.com\/biochemistrysci\/wp-content\/uploads\/2025\/06\/image-8-212x300.png 212w, https:\/\/1dddev.com\/biochemistrysci\/wp-content\/uploads\/2025\/06\/image-8-768x1087.png 768w, https:\/\/1dddev.com\/biochemistrysci\/wp-content\/uploads\/2025\/06\/image-8.png 1085w\" sizes=\"auto, (max-width: 723px) 100vw, 723px\" \/><\/figure>\n\n\n\n<p><strong>&#8220;Discovery of anti-hepatitis B virus activity &#8220;<\/strong><\/p>\n\n\n\n<p>Recently, we have reported that crude extracts of some Thai edible plants contain anti-HBV property. Identification of anti-HBV compounds and their actions inside cells are ongoing. Moreover, we have found an effective siRNA target site that could inhibit the HBV gene expression. Characterisation of this siRNA and investigation of more siRNAs against the HBV gene expression are underway.<\/p>\n\n\n\n<p>Ongoing research projects are:<\/p>\n\n\n\n<p><strong>Natural product study<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Inhibitory effects of crude extracts from some edible Thai plants against replication of hepatitis B virus and human liver cancer cells.<\/li>\n\n\n\n<li>Potential inhibitory effect of Thai medicinal plants on molecular mechanism of hepatitis B virus.<\/li>\n<\/ul>\n\n\n\n<p><strong>RNAi technology<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Identification of effective siRNA target sites on HBV RNA.<\/li>\n<\/ul>\n\n\n\n<p><strong>Examples of publications<\/strong><\/p>\n\n\n\n<div class=\"grid grid-cols-1 !mb-16 gap-x-4 gap-y-3 | lg:grid-cols-2 lg:gap-x-7\">\n\t\t\t\t\t<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&#038;size=200&#038;term=T-Thienprasert+NP&#038;cauthor_id=32739741\" aria-label=\"Pubmed\" target=\"_blank\" class=\"link__card btn-link rounded-xl flex flex-col justify-between overflow-hidden w-full group border-2 border-black\/30 hover:border-primary\">\n\t\t\t\t\n\t\t\t\t\t<div class=\"grid grid-cols-[1fr_18px] gap-0.5 | xl:gap-3 xl:flex justify-between items-end  relative z-10\">\n\t\t\t\t\t\t<span class=\"text-black text-fs14 | lg:text-fs16\">\n\t\t\t\t\t\t\tPubmed\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"icon external\">\n\t\t\t\t\t\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 14 14\" fill=\"none\">\n\t\t\t\t\t\t\t\t\t\t<path fill=\"black\" d=\"M14 1.49998C14 0.947692 13.5523 0.499987 13 0.5L3.99998 0.500212C3.44769 0.500225 2.99999 0.947951 3 1.50024C3.00001 2.05252 3.44774 2.50023 4.00002 2.50021L12 2.50002L12.0002 10.5C12.0002 11.0523 12.448 11.5 13.0002 11.5C13.5525 11.5 14.0002 11.0523 14.0002 10.5L14 1.49998ZM2.39368 13.5211L13.7071 2.20709L12.2929 0.79291L0.979434 12.1069L2.39368 13.5211Z\" \/>\n\t\t\t\t\t\t\t\t\t<\/svg>\n\t\t\t\t\t\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 14 14\" fill=\"none\">\n\t\t\t\t\t\t\t\t\t\t<path fill=\"black\" d=\"M14 1.49998C14 0.947692 13.5523 0.499987 13 0.5L3.99998 0.500212C3.44769 0.500225 2.99999 0.947951 3 1.50024C3.00001 2.05252 3.44774 2.50023 4.00002 2.50021L12 2.50002L12.0002 10.5C12.0002 11.0523 12.448 11.5 13.0002 11.5C13.5525 11.5 14.0002 11.0523 14.0002 10.5L14 1.49998ZM2.39368 13.5211L13.7071 2.20709L12.2929 0.79291L0.979434 12.1069L2.39368 13.5211Z\" \/>\n\t\t\t\t\t\t\t\t\t<\/svg>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\n\t\t\t\t<a href=\"https:\/\/www.scopus.com\/authid\/detail.uri?authorId=57210445387\" aria-label=\"Scopus\" target=\"_blank\" class=\"link__card btn-link rounded-xl flex flex-col justify-between overflow-hidden w-full group border-2 border-black\/30 hover:border-primary\">\n\t\t\t\t\n\t\t\t\t\t<div class=\"grid grid-cols-[1fr_18px] gap-0.5 | xl:gap-3 xl:flex justify-between items-end  relative z-10\">\n\t\t\t\t\t\t<span class=\"text-black text-fs14 | lg:text-fs16\">\n\t\t\t\t\t\t\tScopus\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"icon external\">\n\t\t\t\t\t\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 14 14\" fill=\"none\">\n\t\t\t\t\t\t\t\t\t\t<path fill=\"black\" d=\"M14 1.49998C14 0.947692 13.5523 0.499987 13 0.5L3.99998 0.500212C3.44769 0.500225 2.99999 0.947951 3 1.50024C3.00001 2.05252 3.44774 2.50023 4.00002 2.50021L12 2.50002L12.0002 10.5C12.0002 11.0523 12.448 11.5 13.0002 11.5C13.5525 11.5 14.0002 11.0523 14.0002 10.5L14 1.49998ZM2.39368 13.5211L13.7071 2.20709L12.2929 0.79291L0.979434 12.1069L2.39368 13.5211Z\" \/>\n\t\t\t\t\t\t\t\t\t<\/svg>\n\t\t\t\t\t\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 14 14\" fill=\"none\">\n\t\t\t\t\t\t\t\t\t\t<path fill=\"black\" d=\"M14 1.49998C14 0.947692 13.5523 0.499987 13 0.5L3.99998 0.500212C3.44769 0.500225 2.99999 0.947951 3 1.50024C3.00001 2.05252 3.44774 2.50023 4.00002 2.50021L12 2.50002L12.0002 10.5C12.0002 11.0523 12.448 11.5 13.0002 11.5C13.5525 11.5 14.0002 11.0523 14.0002 10.5L14 1.49998ZM2.39368 13.5211L13.7071 2.20709L12.2929 0.79291L0.979434 12.1069L2.39368 13.5211Z\" \/>\n\t\t\t\t\t\t\t\t\t<\/svg>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\n\n<\/div>\n\n\n<p>1&nbsp;Visootsat, A.,&nbsp;S.&nbsp;Payungporn. and &nbsp;<strong>N.P. T-Thienprasert<\/strong>&nbsp;(2015) A conserved RNA structural elements within the hepatitis B virus post-transcriptional regulatory element enhance nuclear export of intronless transcripts and repress the splicing mechanism.&nbsp;<em>Molecular Biology Reports<\/em>&nbsp;42: 1603.<\/p>\n\n\n\n<ol start=\"2\" class=\"wp-block-list\">\n<li>Thongthae, N., S. Payungporn, Y. Poovorawan and\u00a0<strong>NP\u00a0T-Thienprasert\u00a0<\/strong>(2014) A rational study for identification of highly effective siRNAs against hepatitis B virus.\u00a0<em>Experimental and Molecular Pathology<\/em>. 97:120-127<\/li>\n\n\n\n<li>Issara-Amphorn, J. and\u00a0<strong>NP\u00a0T-Thienprasert<\/strong>. (2014) Preliminary\u00a0<em>in vitro<\/em>\u00a0pro-apoptotic effects of\u00a0<em>Cratoxylum formosum\u00a0<\/em>crude leaf extracts.\u00a0<em>International Journal of Applied Research in Natural Products<\/em>. 7: 26-30.<\/li>\n\n\n\n<li>\u00a0Chen, A.,\u00a0<strong>NP\u00a0T-Thienprasert<\/strong>and CM Brown (2014) Prospects for inhibiting the post-transcriptional regulation of gene expression in hepatitis B virus.\u00a0<em>World Journal of Gastroenterology<\/em>(in press April 2014).<\/li>\n\n\n\n<li>\u00a0\u00a0<a href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S1877750313001440\">Plakunmontho<\/a>n,\u00a0S.,\u00a0<strong>NP<\/strong><a href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S1877750313001440\"><strong>T-Thienprasert<\/strong><\/a><strong>,<\/strong>. K\u00a0<a href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S1877750313001440\">Khongnomnan<\/a>, Y\u00a0<a href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S1877750313001440\">Poovorawan<\/a>,\u00a0and S.\u00a0<a href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S1877750313001440\">Payungporn<\/a>(2014)<sup>\u00a0\u00a0<\/sup>Computational prediction of hybridization patterns between hepatitis C viral genome and human microRNAs.\u00a0<em>Journal of Computational Science.\u00a0<\/em>5: 327-331.<\/li>\n\n\n\n<li>Chanthakan, N., N. Wetprasit, S. Roytrakul, K. Choowongkomon,\u00a0<strong>N. Panjaworayan,\u00a0<\/strong>C. Yokthongwattana, T Arpornsuwan and S. Ratanapo. (2013) Bioactiviies of Jc-SCRIP, atype 1 ribosome-inactivating protein from Jatropha curcas seed coat. Chemical Biology and\u00a0<em>Drug Desig<\/em>n. 82:453-462.<\/li>\n\n\n\n<li>Wanwisa W, S Payungporn, J Issara-Amphorn and\u00a0<strong>NT Panjaworayan<\/strong>. (2012) Inhibitory effects of crude extracts from some edible Thai plants against replication of hepatitis B virus and human liver cancer cells.\u00a0<em>BMC Complementary and Alternative Medicine<\/em>. 12:246.<\/li>\n\n\n\n<li>\u00a0<strong>Panjaworayan, NT\u00a0<\/strong>(2011) Overview of RNA interference therapeutics.\u00a0<em>Songklanakarin Journal of Science and Technology<\/em>. 34:293-301<\/li>\n\n\n\n<li><strong>Panjaworayan, N\u00a0<\/strong>and CM Brown (2011) effects of HBV genetic variability on RNAi strategies.\u00a0<em>Hepatology Research Treatment<\/em>\u00a02011:367908\u00a0<\/li>\n\n\n\n<li><strong>Panjaworayan, N<\/strong>, S Payungporn, Y Poovorawan, and CM Brown (2010) Identification of an effective siRNA target site and functional regulatory elements, within the hepatitis B virus post-transcriptional regulatory element.\u00a0<em>Virology Journal<\/em>\u00a07:216.<\/li>\n\n\n\n<li>Payungporn, S.,\u00a0<strong>N Panjaworayan<\/strong>, J Makkoc., Y Poovorawan (2010) Molecular characteristics of human pandemic influenza A virus (H1N1).\u00a0<em>Acta Virologica<\/em>., 54:155-163.<\/li>\n\n\n\n<li>\u00a0Payungporn, S., T Chieochansin, C Thongmee,\u00a0<strong>N Panjaworayan<\/strong>, R Samransamruajkit, A Theamboolers, Y Poovorawan (2008) Detection and discrimination of WU\/KI polyomaviruses by real-time PCR with melting curve analysis.\u00a0<em>Journal Virology Methods<\/em>\u00a0153: 70-73<\/li>\n\n\n\n<li><strong>Panjaworayan<\/strong>, N., SK Roessner, A Firth and CM Brown (2007) HBVRegDB: Annotation, comparison, detection and visulization of regulatory elements in hepatitis B virus sequences.<em>Virology Journal.<\/em>\u00a04:136.<\/li>\n<\/ol>\n\n\n\n<h2 class=\"wp-block-heading\">Research Grants<\/h2>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><th>\u0e1b\u0e35<\/th><th>\u0e23\u0e32\u0e22\u0e25\u0e30\u0e40\u0e2d\u0e35\u0e22\u0e14<\/th><\/tr><tr><td>2013<\/td><td>Thailand Research Funding (TRF) and the Commission on Higher Education Grant. In \u201cPolypyrimidine tract binding protein (PTB): functions and its interaction \u2028with hepatitis B virus post-transcriptional regulation in living cells\u201d<\/td><\/tr><tr><td>2012<\/td><td>Kasetsart University Research and Development Institute (KURDI) Grant. In \u201cPotential inhibitory effect of Thai vegetables on molecular mechanism of hepatitis B virus\u201d<\/td><\/tr><tr><td>2010<\/td><td>Thailand Research Funding (TRF) and the Commission on Higher Education Grant. In \u201cIdentification of novel siRNA target sites within hepatitis B post-transcriptional regulatory element\u201d<\/td><\/tr><tr><td>2009<\/td><td>Kasetsart University Research and Development Institute (KURDI) grant. In \u201cStudy of post-transcriptional regulation in hepatitis B virus\u201d<\/td><\/tr><tr><td>2008<\/td><td>Thailand Research Funding for Master Project Grant (TRF-MAG). In \u201cIdentification of anti liver cancer and antiviral properties in Thai vegetables\u201d<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Awards<\/h2>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><th>\u0e1b\u0e35<\/th><th>\u0e23\u0e32\u0e22\u0e25\u0e30\u0e40\u0e2d\u0e35\u0e22\u0e14<\/th><\/tr><tr><td>2011<\/td><td>The German Academic Exchange Service (DAAD) Scholarship<\/td><\/tr><tr><td>2005<\/td><td>A student poster winner for virology prize by the Centre for Gene Research (CGR), NZ<\/td><\/tr><tr><td>2005<\/td><td>The Virology Them Award<\/td><\/tr><tr><td>2005<\/td><td>The Biochemistry Them Funding<\/td><\/tr><tr><td>2005<\/td><td>Marjorie McCallum Travel Awards<\/td><\/tr><tr><td>2003<\/td><td>Summer Studentship Scholarship from Child Health Research, New Zealand.<\/td><\/tr><tr><td>1998<\/td><td>Royal Thai Government Scholarship<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Lab Members<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Akasit Visootsat\u00a0(M.Sc. student)<\/li>\n\n\n\n<li>Nattkawee Thongtae\u00a0(M.Sc. student)<\/li>\n\n\n\n<li>Jiraphorn Issara-Amphorn\u00a0(M.Sc. student)<\/li>\n<\/ul>\n","protected":false},"featured_media":35006,"parent":0,"template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-35005","ku-personnel","type-ku-personnel","status-publish","has-post-thumbnail","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u0e23\u0e2d\u0e07\u0e28\u0e32\u0e2a\u0e15\u0e23\u0e32\u0e08\u0e32\u0e23\u0e22\u0e4c \u0e14\u0e23.\u0e13\u0e31\u0e10\u0e19\u0e31\u0e19\u0e17\u0e4c \u0e15.\u0e40\u0e17\u0e35\u0e22\u0e19\u0e1b\u0e23\u0e30\u0e40\u0e2a\u0e23\u0e34\u0e10 - \u0e20\u0e32\u0e04\u0e27\u0e34\u0e0a\u0e32\u0e0a\u0e35\u0e27\u0e40\u0e04\u0e21\u0e35 SCI KU<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/1dddev.com\/biochemistrysci\/ku-personnel\/\u0e23\u0e2d\u0e07\u0e28\u0e32\u0e2a\u0e15\u0e23\u0e32\u0e08\u0e32\u0e23\u0e22\u0e4c-\u0e14\u0e23-\u0e13\u0e31\u0e10\u0e19\u0e31\u0e19\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u0e23\u0e2d\u0e07\u0e28\u0e32\u0e2a\u0e15\u0e23\u0e32\u0e08\u0e32\u0e23\u0e22\u0e4c \u0e14\u0e23.\u0e13\u0e31\u0e10\u0e19\u0e31\u0e19\u0e17\u0e4c \u0e15.\u0e40\u0e17\u0e35\u0e22\u0e19\u0e1b\u0e23\u0e30\u0e40\u0e2a\u0e23\u0e34\u0e10 - \u0e20\u0e32\u0e04\u0e27\u0e34\u0e0a\u0e32\u0e0a\u0e35\u0e27\u0e40\u0e04\u0e21\u0e35 SCI KU\" \/>\n<meta property=\"og:description\" content=\"Fax : +662-561-4627 Education Background Area of Expertise Research Interests Research focus &#8220;Discovery of anti-hepatitis B virus activity &#8220; Recently, we have reported that crude extracts of some Thai edible plants contain anti-HBV property. Identification of anti-HBV compounds and their actions inside cells are ongoing. 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